
 ##############################################################################
 ##############################################################################
 ##                                                                          ##
 ##             TINKER  ---  Software Tools for Molecular Design             ##
 ##                                                                          ##
 ##                          Version 4.1  June 2003                          ##
 ##                                                                          ##
 ##               Copyright (c)  Jay William Ponder  1990-2003               ##
 ##                            All Rights Reserved                           ##
 ##                                                                          ##
 ##############################################################################
 ##############################################################################


 Number of Torsions Used in Derivative Computation :     7

 Generating Seed Point for Potential Energy Surface Scan


    Potential Surface Map       Minimum      1              -15.5786


 Normal Mode Local Search       Minimum      1

    Search Direction   1           Step     18               -9.8421

    Potential Surface Map       Minimum      2               -9.8421

    Search Direction   2           Step     18               -9.8421
    Search Direction   3           Step     17              -13.5930

    Potential Surface Map       Minimum      3              -13.5930

    Search Direction   4           Step     22              -13.5930
    Search Direction   5           Step     13              -15.5786
    Search Direction   6           Step     12              -15.5786
    Search Direction   7           Step     24              -15.5786
    Search Direction   8           Step     29              -16.4946

    Potential Surface Map       Minimum      4              -16.4946

    Search Direction   9           Step     13              -16.4946
    Search Direction  10           Step     23              -14.4406

    Potential Surface Map       Minimum      5              -14.4406


 Normal Mode Local Search       Minimum      2

    Search Direction   1           Step     17              -15.5786
    Search Direction   2           Step     13               -9.8421
    Search Direction   3           Step     22               -8.1022

    Potential Surface Map       Minimum      6               -8.1022

    Search Direction   4           Step     17               -8.1022
    Search Direction   5           Step     35              -12.2114

    Potential Surface Map       Minimum      7              -12.2114

    Search Direction   6           Step     17               -9.8421
    Search Direction   7           Step     12               -9.8421
    Search Direction   8           Step     12               -9.8421
    Search Direction   9           Step     17              -12.2114
    Search Direction  10           Step     24               -9.8421

 Normal Mode Local Search       Minimum      3

    Search Direction   1           Step     22              -16.4946
    Search Direction   2           Step     13              -13.5930
    Search Direction   3           Step     18               -8.0781

    Potential Surface Map       Minimum      8               -8.0781

    Search Direction   4           Step     18               -8.1022
    Search Direction   5           Step     31              -16.4946
    Search Direction   6           Step     16              -13.5930
    Search Direction   7           Step     12              -13.5930
    Search Direction   8           Step     12              -13.5930
    Search Direction   9           Step     24               -2.6715

    Potential Surface Map       Minimum      9               -2.6715

    Search Direction  10           Step     33              -13.5930

 Normal Mode Local Search       Minimum      4

    Search Direction   1           Step     39              -12.2114
    Search Direction   2           Step     11              -16.4946
    Search Direction   3           Step     21              -13.2009

    Potential Surface Map       Minimum     10              -13.2009

    Search Direction   4           Step     36               -8.0647

    Potential Surface Map       Minimum     11               -8.0647

    Search Direction   5           Step     19              -16.4946
    Search Direction   6           Step     44               -4.5073

    Potential Surface Map       Minimum     12               -4.5073

    Search Direction   7           Step     11              -16.4946
    Search Direction   8           Step     12              -16.4946
    Search Direction   9                                      ------
    Search Direction  10           Step     59              -16.4946

 Normal Mode Local Search       Minimum      5

    Search Direction   1           Step      9              -14.4406
    Search Direction   2           Step     32              -12.2114
    Search Direction   3           Step     29               -4.7060

    Potential Surface Map       Minimum     13               -4.7060

    Search Direction   4           Step     28               -4.6383

    Potential Surface Map       Minimum     14               -4.6383

    Search Direction   5           Step     35              -12.2114
    Search Direction   6           Step     41              -12.2114
    Search Direction   7           Step     14              -14.4406
    Search Direction   8           Step     15              -14.4406
    Search Direction   9           Step     34              -14.4406
    Search Direction  10           Step     38              -15.5786

 Normal Mode Local Search       Minimum      6

    Search Direction   1           Step     20               -9.8421
    Search Direction   2           Step     13               -8.1022
    Search Direction   3           Step     15               -8.1022
    Search Direction   4           Step     17              -13.5930
    Search Direction   5           Step     35              -12.2114
    Search Direction   6           Step     17               -8.1022
    Search Direction   7           Step     13               -8.1022
    Search Direction   8           Step     12               -8.1022
    Search Direction   9           Step     35               -8.0781
    Search Direction  10           Step     24               -8.1022

 Normal Mode Local Search       Minimum      7

    Search Direction   1           Step     19              -16.4946
    Search Direction   2           Step     17               -6.4822

    Potential Surface Map       Minimum     15               -6.4822

    Search Direction   3           Step     22               -8.0507

    Potential Surface Map       Minimum     16               -8.0507

    Search Direction   4           Step     23               -8.0507
    Search Direction   5           Step     19              -12.2114
    Search Direction   6           Step     37              -12.2114
    Search Direction   7           Step     12              -12.2114
    Search Direction   8           Step     12              -12.2114
    Search Direction   9           Step     19              -12.2114
    Search Direction  10           Step     16              -12.2114

 Normal Mode Local Search       Minimum      8

    Search Direction   1           Step     15               -8.0781
    Search Direction   2           Step     19              -12.2114
    Search Direction   3           Step     17               -8.1022
    Search Direction   4           Step     16              -13.5930
    Search Direction   5           Step     12               -8.0781
    Search Direction   6           Step     12               -8.0781
    Search Direction   7           Step     31               -8.1022
    Search Direction   8           Step     15               -8.0781
    Search Direction   9           Step     17               -1.1979

    Potential Surface Map       Minimum     17               -1.1979

    Search Direction  10           Step     33               -8.1022

 Normal Mode Local Search       Minimum      9

    Search Direction   1           Step     15               -2.0813

    Potential Surface Map       Minimum     18               -2.0813

    Search Direction   2           Step     14               -7.3451

    Potential Surface Map       Minimum     19               -7.3451

    Search Direction   3           Step     15               -4.7060
    Search Direction   4           Step     37              -12.2114
    Search Direction   5           Step     28              -14.4406
    Search Direction   6           Step     29              -14.4406
    Search Direction   7           Step     38               -8.0781
    Search Direction   8           Step     36               -8.0781
    Search Direction   9           Step     19               -2.6715
    Search Direction  10           Step     31              -13.2009

 Normal Mode Local Search       Minimum     10

    Search Direction   1           Step     18               -8.0781
    Search Direction   2           Step     19               -8.1022
    Search Direction   3           Step     18              -16.4946
    Search Direction   4           Step     18              -16.4946
    Search Direction   5           Step     11              -13.2009
    Search Direction   6           Step     11              -13.2009
    Search Direction   7           Step     52               -2.6715
    Search Direction   8           Step     20              -13.2009
    Search Direction   9           Step     12              -13.5930
    Search Direction  10           Step     23              -13.2009

 Normal Mode Local Search       Minimum     11

    Search Direction   1           Step     12              -13.5930
    Search Direction   2           Step     18              -13.2009
    Search Direction   3           Step     17               -8.0507
    Search Direction   4           Step     17               -8.0507
    Search Direction   5           Step     19              -16.4946
    Search Direction   6           Step     21              -15.5786
    Search Direction   7           Step     12               -8.0647
    Search Direction   8           Step     12               -8.0647
    Search Direction   9           Step     26               -7.3451
    Search Direction  10           Step     21               -4.6383

 Normal Mode Local Search       Minimum     12

    Search Direction   1           Step     10               -4.5073
    Search Direction   2           Step     11              -12.2114
    Search Direction   3           Step     23               -2.5222

    Potential Surface Map       Minimum     20               -2.5222

    Search Direction   4           Step     17               -2.5222
    Search Direction   5           Step     37              -16.4946
    Search Direction   6           Step     21              -16.4946
    Search Direction   7           Step     46               -6.4822
    Search Direction   8           Step     17               -4.5073
    Search Direction   9           Step     34               -6.4822
    Search Direction  10           Step     26               -6.4822

 Normal Mode Local Search       Minimum     13

    Search Direction   1           Step     16               -2.0813
    Search Direction   2           Step     13               -2.6715
    Search Direction   3           Step     20                1.2799

    Potential Surface Map       Minimum     21                1.2799

    Search Direction   4           Step     19                1.2799
    Search Direction   5           Step     22              -14.4406
    Search Direction   6           Step     22              -14.4406
    Search Direction   7           Step     14               -4.7060
    Search Direction   8           Step     12               -4.7060
    Search Direction   9           Step     23               -4.7060
    Search Direction  10           Step     18               -7.3451

 Normal Mode Local Search       Minimum     14

    Search Direction   1           Step     11               -8.0647
    Search Direction   2           Step     37               -8.1022
    Search Direction   3           Step     17               -4.7060
    Search Direction   4           Step     16               -4.6383
    Search Direction   5           Step     18              -14.4406
    Search Direction   6           Step     17              -14.4406
    Search Direction   7           Step     24               -8.0507
    Search Direction   8           Step     49               -8.0507
    Search Direction   9           Step     17               -4.7060
    Search Direction  10           Step     19               -7.3451

 Normal Mode Local Search       Minimum     15

    Search Direction   1           Step     14              -12.2114
    Search Direction   2           Step     12              -12.2114
    Search Direction   3           Step     29                1.2799
    Search Direction   4           Step     17                1.2799
    Search Direction   5           Step     24              -16.4946
    Search Direction   6           Step     24              -15.5786
    Search Direction   7           Step     44               -6.4822
    Search Direction   8           Step     22               -6.4822
    Search Direction   9           Step     16               -4.5073
    Search Direction  10           Step     18               -6.4822

 Normal Mode Local Search       Minimum     16

    Search Direction   1           Step     12               -8.0507
    Search Direction   2           Step     16               -8.1022
    Search Direction   3           Step     18               -8.0647
    Search Direction   4           Step     22               -8.0647
    Search Direction   5           Step     19              -12.2114
    Search Direction   6           Step     19              -12.2114
    Search Direction   7           Step     29                1.2799
    Search Direction   8           Step     45                2.4973

    Potential Surface Map       Minimum     22                2.4973

    Search Direction   9           Step     20               -8.0507
    Search Direction  10           Step     14               -8.0507

 Normal Mode Local Search       Minimum     17

    Search Direction   1           Step      7               -2.5222
    Search Direction   2           Step     14               -8.1022
    Search Direction   3           Step     22               -4.5073
    Search Direction   4           Step     12               -1.1979
    Search Direction   5           Step     23              -13.5930
    Search Direction   6           Step     23              -13.5930
    Search Direction   7           Step     14               -1.1979
    Search Direction   8                                      ------
    Search Direction   9           Step     39               -1.1979
    Search Direction  10           Step     16               -1.1979

 Normal Mode Local Search       Minimum     18

    Search Direction   1           Step     19              -14.4406
    Search Direction   2           Step     18               -4.6383
    Search Direction   3           Step     17               -2.5222
    Search Direction   4           Step     17               -8.0781
    Search Direction   5           Step     24               -4.6383
    Search Direction   6                                      ------
    Search Direction   7           Step     12               -2.0813
    Search Direction   8           Step     12               -2.0813
    Search Direction   9           Step     19              -13.2009
    Search Direction  10           Step     20              -13.2009

 Normal Mode Local Search       Minimum     19

    Search Direction   1           Step     29              -16.4946
    Search Direction   2           Step      9               -7.3451
    Search Direction   3           Step     17               -8.0507
    Search Direction   4           Step     17               -8.0507
    Search Direction   5           Step     21              -15.5786
    Search Direction   6           Step     21              -16.4946
    Search Direction   7           Step     17               -7.3451
    Search Direction   8           Step     36               -8.0647
    Search Direction   9           Step     20               -4.6383
    Search Direction  10           Step      9               -8.0647

 Normal Mode Local Search       Minimum     20

    Search Direction   1           Step     19               -8.0781
    Search Direction   2           Step     24               -8.1022
    Search Direction   3           Step     17               -4.5073
    Search Direction   4           Step     21               -4.5073
    Search Direction   5           Step     22              -13.2009
    Search Direction   6           Step     25              -13.2009
    Search Direction   7           Step     13               -1.1979
    Search Direction   8           Step     22               -8.0507
    Search Direction   9           Step     13               -2.5222
    Search Direction  10           Step     12               -2.5222

 Normal Mode Local Search       Minimum     21

    Search Direction   1           Step     10               -1.1979
    Search Direction   2           Step     11                1.2799
    Search Direction   3           Step     12               -8.0507
    Search Direction   4           Step     17               -8.0507
    Search Direction   5           Step     33               -4.5073
    Search Direction   6           Step     15                1.2799
    Search Direction   7           Step     17                1.2799
    Search Direction   8           Step     28               -8.0507
    Search Direction   9           Step     17                1.2799
    Search Direction  10           Step     40               -4.5073

 Normal Mode Local Search       Minimum     22

    Search Direction   1           Step     10                2.4973
    Search Direction   2           Step     33               -7.3451
    Search Direction   3           Step     12                1.2799
    Search Direction   4           Step     32              -12.2114
    Search Direction   5           Step     19                2.4973
    Search Direction   6           Step     19                2.4973
    Search Direction   7           Step     24                1.2799
    Search Direction   8           Step     16               -8.0507
    Search Direction   9           Step     29               -8.0647
    Search Direction  10           Step     24                1.2799
